Cialis vs Viagra vs Levitra
What comes to your mind when you hear about erectile dysfunction? Perhaps you think about a man looking stressed and desperate to find a solution. Or if you had an experience with the condition, probably you know that it is not something similar to terminal cancer or a death sentence. As they say, no condition is permanent and thank goodness because erectile dysfunction just happened to be among the treatable conditions. You are not going to be disappointed with your search of ways to regain your virility, but that’s only if you are willing to work for that. You won’t get that firm erection just by sitting in your bedroom, face cupped in your hands, thinking about the disgrace that’s come over you. It all begins with seeking medical attention and the best way to do this would be paying your doctor a visit. Well, the physician is the one to decide here, but you can be sure that the prescription coming your way is an ED drug. And your list of choices isn’t so long. You either have Sildenafil, Tadalafil or Vardenafil. That is if we looked at it from the chemical perspective. The marketing departments of manufacturers have all sorts of trade names to ED drugs, but basically, these three are the active ingredients that trigger the good old healthy erection you desire. In this text, we are going to look at how the three top ED drugs on the market compare. What would be the score if we put Cialis vs Viagra, Levitra vs Viagra or Cialis vs Levitra?
If you have been to the hospital seeking help with your sexual health problems, then you probably have heard of Cialis. This drug was the brainchild of ICOS Company, but due to some occurrences along its course, it has now become a product sold by ICOS and Eli Lilly.
Cialis is just the brand name. What gives the drug its functionality is the tadalafil that is found in it. Tadalafil is the active ingredient in Cialis just like Sildenafil in Viagra. Tadalafil was discovered way back in the 90s as an erectile dysfunction medication. The initial intention was not actually to manufacture an ED drug but somehow along the way things changed, especially after Pfizer also incidentally discovered that Tadalafil’s analogue, Sildenafil, could treat erectile dysfunction.
The mechanism of how Cialis exerts its effects to ultimately produce an erection in a person with impotence is worth knowing. The Tadalafil is an inhibitor of an enzyme that is called phosphodiesterase 5 (PDE5). This enzyme is responsible for interfering with the regular healthy erection mechanisms. How does this happen? When the man is sexually excited, his body releases nitric oxide which further stimulates the production of cyclic guanylyl monophosphate (cGMP). The cyclic GMP causes the relaxation of the smooth muscles of the blood vessels in the penis, and this allows more blood to flow into the penile tissue. PDE 5 then comes to cleave the cyclic GMP and in the process, stops the erection. It, therefore, goes without saying that when PDE 5 is inhibited, the morning wood can be firm for as long as it wants. And that is just how Tadalafil brings about an erection. However, there has to be sexual stimulation for the effects of Cialis to be felt.
Cialis can be used either as a daily dosage drug or as a use-when-needed medication. In the former case, the doctor will often prescribe the lower strengths −2.5mg or 5mg. The pills are then taken daily, and any time between the doses a firm erection can be elicited. The use-when-needed medications usually come in higher strengths such as the 10mg or 20mg. In some cases, even the 5mg Cialis can be utilized when needed. These ought to be taken about 30 minutes before the expected sexual activity.
Cialis is a favorite of many men with ED because it has a very long half-life. Some people have reported feeling the effects of the drug up to 72 hours after taking it. What’s more, tadalafil can have a very rapid onset of action. The earliest the drug can act is about 15 minutes after ingestion and the long duration of its effect in the body guarantees you no need for pills in the next two or three days.
To many people, the mention of the word impotence conjures up images of a blue diamond-shaped pill which is well known for its effects of combating the condition. Viagra is no doubt a major player in the market among ED drugs. It is a product of Pfizer research institute which happened to come across sildenafil and incidentally found out that it could act as an ED drug. This happened when Pfizer was testing sildenafil as a drug to be used for relieving the symptoms of angina pectoris. FDA approved sildenafil for use in ED patients in 1996 and Pfizer immediately obtained patent on the use of the compound.
Sildenafil also acts by inhibiting the PDE 5 enzyme in a similar manner with that of tadalafil. When PDE 5 is inhibited, there is a maintained erection due to the continued vasodilation that stays uninterrupted as long as sildenafil remains active. This goes on for up to six hours. The average half-life of Sildenafil is four hours. The drug has to be taken when one is anticipating sex, approximately thirty to forty-five minutes before it. It is recommended that only a single pill of Viagra is taken within a period of 24 hours to avoid possible adverse effects. The common strengths of Viagra are the 25mg, 50mg, and 100mg. Many physicians typically recommend starting on a 50mg dose and then later increasing it to 100mg or lowering it to 25mg after judging from the effects of the 50mg dosage.
The patent that was awarded to Pfizer on the use of sildenafil as an ED medication has long expired in some countries giving way to the generic manufacturers. As a result, you are bound to find sildenafil under very many names on the market. However, the brand name Viagra still stands out, and its sells have not dropped significantly. However, many buyers in the United States are now seeking cheap generics from foreign countries and maybe the time for Pfizer to feel the pinch is nigh.
As you would expect with any drugs, Viagra also has side effects associated with it, and some of these are headaches, flushing, back pains, nausea, rashes and nasal congestion. More often than not, these signs are very mild, and they will fade away with time. However, any adversities need to be reported to the doctor as quickly as possible.
The common drug interactions that have been studied for Viagra include those with nitrate-containing compounds. In this case, there will be a marked drop in blood pressure because both Viagra and Nitrates work by causing vasodilation. Also, the use of cimetidine and imatinib is not recommended along with Viagra. You should also avoid taking grapefruit with Viagra because the juice blocks the breakdown of sildenafil leading to its accumulation in the body.
Levitra is an erectile dysfunction drug that is sold by Bayer Pharmaceuticals and GSK. The active ingredient in Levitra is Vardenafil. The compound is a potent inhibitor if cyclic GMP which is very active in the corpus caverosum. During sexual stimulation, nitric oxide is released in the penile tissues, and it causes relaxation of smooth muscles which encourages the flow of blood into the penis. Nitric oxide induces its effects via cyclic GMP. The cyclic GMP is broken down by PDE 5 and vardenafil works by inhibiting PDE 5.
Levitra is an oral medication which is rapidly absorbed from the gastrointestinal tract. Some users have reported feeling the effects of vardenafil as early as 15 minutes after ingestion. However, the average onset of action is 30 to 120 minutes in fasting states. The tablets are film-coated, and they come in different strengths, namely 5mg, 10mg, and 20mg. The half-life of Levitra is about 4 hours. Levitra is a use-when-needed med that should be taken when an individual is expecting sexual activity – about an hour prior to it. It is recommended that only a single dosage of Vardenafil should be taken within 24 hours. The dosage is best determined by the physician. It is, therefore, advisable to use Levitra as a prescription only medication. Monitoring by the doctor is also necessary. You have to report what you are feeling and the progress of your status in the course of the treatment with this medication. The interactions of vardenafil with other substances should be assessed carefully before proceeding with the therapy. Some drugs such as nitrates should not be used concomitantly with Viagra because the two are very likely to cause a drop in blood pressure. This is also the case with alpha blockers that are used in managing benign prostate hyperplasia and hypertension.
The common side effects that are associated with the use of Levitra are headaches, flushing, nasal congestion and visual disturbances. Dizziness and lightheadedness may also come as a result of Levitra consumption.
The Levitra pills are marketed as orange pills with the words “Bayer” imprinted on one side and the strength on the other side.
It has also been proven that Levitra can be used as a remedy for premature ejaculation.
One has to take some precautions before resorting to using Levitra. The best thing is to obtain a prescription from the doctor, and this has to come after careful evaluation of the medical history of the patient. People with allergies to any of the products found in Levitra pills should obviously avoid using the medication.
Tadalafil vs Sildenafil
When it’s Viagra vs Cialis (sildenafil vs tadalafil), you have to make a choice. Which medication are you going for? That can present a serious dilemma because if you do not have the facts regarding these drugs, then you will not be in a position to make the right choice. Let us take a look at what you can pick if you have tadalafil and sildenafil as your options. This would mean choosing between Viagra and Cialis or any generic versions thereof. You have to go through the various aspects of each of the two drugs before you can choose the one that suits you best.
What brings out the significant difference between Cialis and Viagra is the active ingredient. Viagra has sildenafil as its active ingredient whereas Cialis contains Tadalafil. The naming and the chemical structures are as far as the differences go. These two compounds are all inhibitors of the same enzyme − PDE 5 − and they exert their effects in a similar fashion.
Regarding the onset of action and the duration of action, tadalafil is obviously the winner. Whereas sildenafil takes an average of 30 minutes for its effect to become tangible, tadalafil can start working as early as 15 minutes after ingestion of the drug. Once absorbed, sildenafil will be active for four to six hours but its counterpart can last for up to three days.
Tadalafil can be taken with food or without food. The presence of food in the gut does not affect tadalafil absorption significantly. On the other hand, sildenafil is best taken without food because food affects its absorption greatly. However, both the drugs should not be taken with grapefruit or grapefruit juice because it impairs their metabolism.
Both of the drugs (Viagra and Cialis) are considered to be prescription only medications in most countries of the world. They can rarely be bought over the counter. Although some pharmacies will offer you the simpler option, it is preferable that you obtain a valid prescription. This ensures that your health issues have all been taken into account and the efficacy of the therapy is no doubt.
The dosages of Cialis are sold as 2.5mg, 5mg, 10mg and 20mg. Viagra is sold in strengths of 25mg, 50mg, and 100mg.
Since both tadalafil and sildenafil have a common mode of action, their side effects are almost similar. Both drugs are likely cause flushing, headaches and a stuffy nose. Other, more serious adverse effects are possible but by no means likely to take place.
Tadalafil vs Vardenafil
When it’s Levitra vs Cialis, the differences are not that easy to spot. Both vardenafil and tadalafil are inhibitors of PDE 5. The mode of action is similar to that of sildenafil; they inhibit the degradation of cyclic GMP. Therefore, it allows the smooth muscles of the penile tissue to relax causing blood to flow in leading to an erection.
The strengths of tadalafil currently present on the market are 2.5mg, 5mg, 10mg, and 20mg. The concentrations of vardenafil are also the same, and both drugs are taken orally.
Tadalafil has a long half-life. The drug can stay active in the body for as long as 36 hours. This lessens the burden of ingesting the drugs on the user. One pill can be taken, and you will need no other until the third day. Vardenafil, on the other hand, is no different from sildenafil when it comes down to the duration of action. Vardenafil lasts for about 4 hours after its ingestion and should, therefore, be taken when the user is expecting sexual activity in the next hour. Tadalafil can be used both as needed and as a daily dosage medication. The onset of action of the two drugs also varies. Whereas tadalafil will start producing its effects in the as early as 15 to 30 minutes after ingestion, it takes vardenafil about an hour to start producing its effect.
In most pharmacies you will see Tadalafil sold as Cialis whereas Vardenafil is sold under the brand name Levitra. The former is manufactured and sold by Lilly and ICOS and Levitra is a product of Bayer.
Both Tadalafil and Vardenafil are well tolerated by the body, and their absorption is not compromised by food intake. High-fat meals together with some drugs such as ketoconazole can, however, impair the digestion of both drugs.
Expect similar side effects when you use tadalafil or vardenafil because the two meds have the same mechanism of action. Some of the common side effects include headaches, flushing, nasal congestion and nausea.
Vardenafil vs Sildenafil
Vardenafil and sildenafil are both PDE 5 inhibitors. They raise the quality of sex by increasing time and strength of the erection. This happens because the cyclic GMP released in sexual stimulation remains active for longer when someone is using the PDE 5 inhibitors. Therefore, blood flow to the penis is increased. Vardenafil came into the market a few years after sildenafil. Sildenafil was actually the first really effective ED drug ever, being approved by FDA in 1998 whereas Levitra came in 2003. Vardenafil is manufactured by Bayer and Viagra is a product of Pfizer.
It is recommended that Levitra should be taken about an hour before sexual activity. However, it has been shown that the drug can start acting earlier than that. For Viagra, the onset of action is about 30 minutes.
Levitra comes in strengths of 2.5mg, 5mg, 10mg and 20 mg. Viagra comes as 25mg, 50mg and 100mg pills.
Vardenafil can be taken with or without food. Its metabolism is not affected by food because it is absorbed in small amounts over a long time. For sildenafil, absorption can be affected by eating some foods such as fatty acids and grapefruits. Sildenafil works slower in people on a diet rich in fats.
When faced with a decision to make regarding which ED to buy, you have to put a number of factors into consideration. It has to be a therapy specifically meant for you. It is, therefore, important to find out the unique characteristics that each drug has. The aspect of cost also comes to play. Just buy what you can afford. The ED drugs do not actually cure the condition, but they offer momentary relief. Therefore, you have to choose what your pocket can sustain. Most importantly, always remember to use the drugs that are safe for you. You are better off in the hands of a physician. And don't forget to report your progress to the medic now and then just to make sure that no problems develop in the course of your therapy.